Matrine

Matrine is an alkaloid found in plants from the family Fabaceae. It has a variety of pharmacological effects, including in-vitro anti-cancer effects,^[1] as well as κ-opioid and μ-opioid receptor agonism.^[2][3]

Matrine

Clinical data
ATC code	none
Legal status
Legal status	Unscheduled, sold OTC in US
Identifiers
IUPAC name (1R,2R,9S,17S)-7,13-Diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
CAS Number	519-02-8 Y
PubChem CID	91466
ChemSpider	82591 N
UNII	N390W430AC
KEGG	C10774 N
ChEBI	CHEBI:6700 N
ChEMBL	ChEMBL204860 N
CompTox Dashboard (EPA)	DTXSID00274188
ECHA InfoCard	100.117.486
Chemical and physical data
Formula	C15H24N2O
Molar mass	248.370 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
InChI InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 N Key:ZSBXGIUJOOQZMP-JLNYLFASSA-N N
NY (what is this?)  (verify)

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.^[4] Matrine can be commercially extracted from the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated.

Matrine and the related compound oxymatrine have a toxic effect against the formosan subterranean termite.^[5] Additionally, it acts as a nematicide against the pine wood nematode which causes pine wilt,^[6] as well as pathogenic nematodes which target humans.^[7]

Matrine alleviates neuro-inflammation and oxidative stress in the brain caused by acute liver injury, thus producing antianxiety and antidepression effects.^[8]