Matriptase

Matriptases (EC 3.4.21.109) are an enzyme family.^[1][2] This enzyme cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position

Matriptase
Identifiers
EC no.	3.4.21.109
CAS no.	241475-96-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Peptidase S1A, matripase
Identifiers
Symbol	S1A
InterPro	IPR017051
Membranome	1287

This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. It belongs to proteases of PA superfamily.

Human matriptases

• ST14, also known as matriptase
• TMPRSS6, also known as matriptase 2