Top Qs
Timeline
Chat
Perspective

Membrane-bound transcription factor site-1 protease

Mammalian protein found in Homo sapiens From Wikipedia, the free encyclopedia

Membrane-bound transcription factor site-1 protease
Remove ads

Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme (EC 3.4.21.112) that in humans is encoded by the MBTPS1 gene.[5] S1P cleaves the endoplasmic reticulum loop of sterol regulatory element-binding protein (SREBP) transcription factors.[6][7]

Quick Facts MBTPS1, Identifiers ...
Remove ads
Remove ads

Function

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the endoplasmic reticulum (ER) to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues.[5]

Remove ads

Clinical significance

Mutations in this gene may be associated with lysosomal dysfunction.[5]

See also

References

Loading content...
Loading content...
Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads