Meprin B

Meprin B (EC 3.4.24.63, meprin-b) is an enzyme.^[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His⁵-Leu-, -Leu⁶-Cys-, -Ala¹⁴-Leu- and -Cys¹⁹-Gly- bonds in insulin B chain

Meprin B
Identifiers
EC no.	3.4.24.63
CAS no.	150679-52-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Even though it is primarily found and embedded into the cell membrane it can also be found in the extracellular space.^[5] Like other meprins it can hydrolyze different molecules.^[5]

This membrane-bound metalloendopeptidase is present in mouse intestines.