Methallenestril

Methallenestril
Clinical data
Trade names	Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril (also spelled Vallestrol or Vallestryl)
Other names	Methallenoestril; Methallenestrol; Methallenoestrol; Horeau's acid; Allenestrol 6-methyl ether; α,α-Dimethyl-β-ethylallenolic acid 6-methyl ether; β-Ethyl-6-methoxy-α,α-dimethyl-2-naphthalenepropionic acid
Routes of; administration	By mouth
Drug class	Nonsteroidal estrogen
ATC code	G03CB03 (WHO) ; G03CC03 (WHO);
Identifiers
	IUPAC name 3-(6-Methoxynaphthalen-2-yl)-2,2-dimethylpentanoic acid;
CAS Number	517-18-0;
PubChem CID	10599;
ChemSpider	10154;
UNII	XL025389JS;
CompTox Dashboard (EPA)	DTXSID7023275 ;
ECHA InfoCard	100.007.485
Chemical and physical data
Formula	C18H22O3
Molar mass	286.371 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(c1ccc2cc(OC)ccc2c1)C(C)(C)C(=O)O;
	InChI InChI=1S/C18H22O3/c1-5-16(18(2,3)17(19)20)14-7-6-13-11-15(21-4)9-8-12(13)10-14/h6-11,16H,5H2,1-4H3,(H,19,20); Key:KHLJKRBMZVNZOC-UHFFFAOYSA-N;
	(verify)

Methallenestril (INNTooltip International Nonproprietary Name) (brand names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril), also known as methallenoestril (BANTooltip British Approved Name) and as methallenestrol, as well as Horeau's acid,^[1]^[2] is a synthetic nonsteroidal estrogen and a derivative of allenolic acid and allenestrol (specifically, a methyl ether of it) that was formerly used to treat menstrual issues but is now no longer marketed.^[3]^[4]^[5]^[6] It is a seco-analogue of bisdehydrodoisynolic acid, and although methallenestril is potently estrogenic in rats, in humans it is only weakly so in comparison.^[7] Vallestril was a brand of methallenestril issued by G. D. Searle & Company in the 1950s.^[8] Methallenestril is taken by mouth.^[9] By the oral route, a dose of 25 mg methallenestril is approximately equivalent to 1 mg diethylstilbestrol, 4 mg dienestrol, 20 mg hexestrol, 25 mg estrone, 2.5 mg conjugated estrogens, and 0.05 mg ethinylestradiol.^[9]

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