Methylglyoxal reductase (NADPH-dependent)

In enzymology, a methylglyoxal reductase (NADPH-dependent) (EC 1.1.1.283) is an enzyme that catalyzes the chemical reaction

lactaldehyde + NADP⁺ ${\displaystyle \rightleftharpoons }$ methylglyoxal + NADPH + H⁺

methylglyoxal reductase (NADPH-dependent)
Identifiers
EC no.	1.1.1.283
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are lactaldehyde and NADP⁺, whereas its 3 products are methylglyoxal, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is lactaldehyde:NADP⁺ oxidoreductase. Other names in common use include lactaldehyde dehydrogenase (NADP⁺), and Gre2.