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Methylnitronitrosoguanidine

Chemical compound From Wikipedia, the free encyclopedia

Methylnitronitrosoguanidine
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Methylnitronitrosoguanidine (MNNG[2] or MNG, NTG when referred to colloquially as nitrosoguanidine[3]) is a biochemical tool used experimentally as a carcinogen and mutagen.[1] It acts by adding alkyl groups to the O6 of guanine and O4 of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.

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In organic chemistry, MNNG is used as a source of diazomethane when reacted with aqueous potassium hydroxide.[4]

MNNG is a probable human carcinogen listed as an IARC Group 2A carcinogen.[5]

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Stability

MNNG produces diazomethane, a known methylating agent of DNA and other substrates, in basic aqueous solutions, and nitrous acid, a mutagen, in acidic solutions.[6]

References

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