Methylprednisolone aceponate

Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednisolone.^[2][3][4]

Methylprednisolone aceponate

Clinical data
Trade names	Advantan, Avancort, others
Other names	Methylprednisolone 17α-propionate 21-acetate; ZK-91588
AHFS/Drugs.com	Consumer Drug Information
ATC code	D07AC14 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)[1]
Identifiers
CAS Number	86401-95-8 Y
PubChem CID	63019
DrugBank	DB14643 Y
ChemSpider	56717 N
UNII	ET54W9J4U2
ChEBI	CHEBI:135762
ChEMBL	ChEMBL1697782
CompTox Dashboard (EPA)	DTXSID2023301
ECHA InfoCard	100.184.880
Chemical and physical data
Formula	C27H36O7
Molar mass	472.578 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2C[C@@H](C4=CC(=O)C=C[C@]34C)C)O)C)C(=O)COC(=O)C
InChI InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1 N Key:DALKLAYLIPSCQL-YPYQNWSCSA-N N
NY (what is this?)  (verify)

In Russia and some other countries the drug is available in 4 dosage forms differing in consistency and water content: emulsion (or lotion), cream, ointment and fatty ointment.^[5]

Synthesis

ChemDrug Synthesis:^[6][7] Patent:^[8]

• methylprednisolone [83-43-2] (1)
• Triethyl orthopropionate [115-80-0] (2)
• PC13131717 (3)
• [79512-61-1] (4)

See also

• List of corticosteroid esters § Methylprednisolone esters