Methylthioribulose 1-phosphate dehydratase

The enzyme methylthioribulose 1-phosphate dehydratase (EC .2.1.109) catalyzes the chemical reaction

5-(methylsulfanyl)-D)ribulose 1-phosphate ${\displaystyle \rightleftharpoons }$ 5-(methylthio)-2,3-dioxopentyl phosphate + H₂

methylthioribulose 1-phosphate dehydratase
X-ray structure of human methylthioribulose 1-phosphate dehydratase (APIP). PDB entry 4m6r[1]
Identifiers
EC no.	4.2.1.109
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]. Other names in common use include 1-PMT-ribulose dehydratase, and S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase. This enzyme participates in methionine metabolism.