Mevaldate reductase

In enzymology, a mevaldate reductase (EC 1.1.1.32) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + NAD⁺ ${\displaystyle \rightleftharpoons }$ mevaldate + NADH + H⁺

mevaldate reductase (NAD+)
Identifiers
EC no.	1.1.1.32
CAS no.	9028-33-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are (R)-mevalonate and NAD⁺, whereas its 3 products are mevaldate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD⁺ oxidoreductase. This enzyme is also called mevalonic dehydrogenase.

In 2022, this entry was deleted from the Enzyme Classification, and is now included in with the entry for Alcohol dehydrogenase.^[1]