Mg2+-importing ATPase

In enzymology, a Mg²⁺-importing ATPase (EC 3.6.3.2) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + Mg₂+out ${\displaystyle \rightleftharpoons }$ ADP + phosphate + Mg₂+in

magnesium-importing ATPase
Identifiers
EC no.	3.6.3.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, H₂O, and Mg²⁺, whereas its 3 products are ADP, phosphate, and Mg²⁺.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (Mg²⁺-importing).

The mgtA gene which encodes this enzyme is thought to be regulated by a magnesium responsive RNA element.^[1] A human enzyme was found in erythrocytes^[2] but the observation could not be confirmed.