MIR146A

MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.^[3]

MIR146A
Identifiers
Aliases	MIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A, microRNA 146a
External IDs	OMIM: 610566; GeneCards: MIR146A; OMA:MIR146A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,485,352 bp[1] End 160,485,450 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney epithelium glomerulus prostate gastrocnemius muscle tibial arteries left lobe of thyroid gland blood skin of abdomen spleen n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406938 n/a Ensembl ENSG00000283733 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 5: 160.49 – 160.49 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[3]