MicF RNA

The micF RNA is a non-coding RNA stress response gene found in Escherichia coli and related bacteria that post-transcriptionally controls expression of the outer membrane porin gene ompF.^[1] The micF gene encodes a non-translated 93 nucleotide antisense RNA that binds its target ompF mRNA and regulates ompF expression by inhibiting translation and inducing degradation of the message. In addition, other factors, such as the RNA chaperone protein StpA also play a role in this regulatory system. The expression of micF is controlled by both environmental and internal stress factors. Four transcriptional regulators are known to bind the micF promoter region and activate micF expression.

MicF RNA
Predicted secondary structure and sequence conservation of MicF
Identifiers
Symbol	MicF
Rfam	RF00033
Other data
RNA type	Gene; antisense
Domain(s)	Bacteria
GO	GO:0006950 GO:0003729
SO	SO:0000383
PDB structures	PDBe

Species distribution

Homologues of MicF RNA have been characterised by Southern blotting in a variety of bacteria including Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa.^[2] MicF has also been identified computationally in Yersinia pestis and Yersinia enterocolitica.^[3]