Missouri Route 221

Route 221 is a 16.317-mile-long (26.260 km) east–west highway in eastern Missouri. Its western terminus is at Route 21 near Pilot Knob. Its eastern terminus is at U.S. Route 67 (US 67) near Farmington.

Route 221
MO 221 highlighted in red
Route information
Maintained by MoDOT
Length	16.317 mi[1] (26.260 km)
Existed	c. 2010–2012–present
Major junctions
West end	Route 21 near Pilot Knob
East end	US 67 near Farmington
Location
Country	United States
State	Missouri
Counties	Iron, St. Francois
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 215 → Route 224

Major intersections

County	Location	mi[1]	km	Destinations	Notes
Iron	​	0.000	0.000	Route 21
St. Francois	​	9.040	14.548	Route NN
	Doe Run	12.744	20.509	Route B
	​	16.140– 16.317	25.975– 26.260	US 67 / Route W	Diverging diamond interchange, existing interchange converted September 2012[2]
1.000 mi = 1.609 km; 1.000 km = 0.621 mi