Mozenavir

Mozenavir (DMP-450) is an antiviral drug which was developed as a treatment for HIV/AIDS. It acts as an HIV protease inhibitor and binds to this target with high affinity,^[1][2] however despite promising results in early testing,^[3][4] mozenavir was unsuccessful in human clinical trials. Studies continue into related derivatives.^[5]

Mozenavir

Clinical data
Trade names	Mozenavir
Legal status
Legal status	US: Investigational New Drug
Identifiers
IUPAC name (4R,5S,6S,7R)-1,3-bis[(3-aminophenyl)methyl]-4,7-dibenzyl-5,6-dihydroxy-1,3-diazepan-2-one
CAS Number	174391-92-5
PubChem CID	154044
ChemSpider	135759
UNII	64OO8946ER
CompTox Dashboard (EPA)	DTXSID40169822
Chemical and physical data
Formula	C33H36N4O3
Molar mass	536.676 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C[C@@H]2[C@@H]([C@H]([C@H](N(C(=O)N2CC3=CC(=CC=C3)N)CC4=CC(=CC=C4)N)CC5=CC=CC=C5)O)O
InChI InChI=1S/C33H36N4O3/c34-27-15-7-13-25(17-27)21-36-29(19-23-9-3-1-4-10-23)31(38)32(39)30(20-24-11-5-2-6-12-24)37(33(36)40)22-26-14-8-16-28(35)18-26/h1-18,29-32,38-39H,19-22,34-35H2/t29-,30-,31+,32+/m1/s1 Key:KYRSNWPSSXSNEP-ZRTHHSRSSA-N