Multicenter Automatic Defibrillator Implantation Trial
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Multicenter Automatic Defibrillator Implantation Trial[1] and MADIT II[2] are implantable cardioverter defibrillator (or ICD) trials which investigate whether prophylactic ICD therapy in moderately high-risk coronary patients (in addition to conventional therapy) would significantly reduce death compared with patients treated with conventional therapy alone.
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The MADIT II trial started in 1997 and ended in 2001 where the safety committee stopped the study because the benefits were already statistically significant.
The study included patients with a prior myocardial infarction and an ejection fraction less than or equal to 30%.
The results were a reduction in mortality of 31% compared to patients receiving conventional therapy alone.
References
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