N ,N -Dimethylsphingosine (also known as DMS ) is an inhibitor of sphingosine kinase .[ 1] [ 2]
Quick facts Names, Identifiers ...
N ,N -Dimethylsphingosine
Names
Preferred IUPAC name
(2R ,3S ,4E )-2-(Dimethylamino)octadec-4-ene-1,3-diol
Other names
DMS, N,N-DMS
Identifiers
ChEBI
ChEMBL
ChemSpider
UNII
InChI=1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m1/s1 Y
Key: YRXOQXUDKDCXME-QWKHPXNBSA-N Y
InChI=1/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m1/s1
Key: YRXOQXUDKDCXME-QWKHPXNBBF
CCCCCCCCCCCCC/C=C/[C@@H]([C@@H](CO)N(C)C)O
Properties
C 20 H 41 N O 2
Molar mass
327.553 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25
°C [77
°F], 100
kPa).
Close
In rats with neuropathic pain , the natural metabolite DMS is unregulated in the dorsal horn . Furthermore, DMS induces mechanical hypersensitivity when injected into rats.[ 3]