N-acetylphosphatidylethanolamine-hydrolysing phospholipase D

N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase.^[1][2] It catalyses the following chemical reaction

N-acylphosphatidylethanolamine + H₂O ${\displaystyle \rightleftharpoons }$ N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate

N-acetylphosphatidylethanolamine-hydrolysing phospholipase D
Identifiers
EC no.	3.1.4.54
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is involved in the biosynthesis of anandamide.

See also

• Endocannabinoid System
• N-acyl phosphatidylethanolamine