NAD(P)H-hydrate epimerase

NAD(P)H-hydrate epimerase (EC 5.1.99.6, NAD(P)HX epimerase) is an enzyme with systematic name (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase.^[1] This enzyme catalyses the following chemical reaction

(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ${\displaystyle \rightleftharpoons }$ (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate ${\displaystyle \rightleftharpoons }$ (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

NAD(P)H-hydrate epimerase
Identifiers
EC no.	5.1.99.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.