NADH dehydrogenase

NADH dehydrogenase is an enzyme that converts nicotinamide adenine dinucleotide (NAD) from its reduced form (NADH) to its oxidized form (NAD⁺). Members of the NADH dehydrogenase family and analogues are commonly systematically named using the format NADH:acceptor oxidoreductase.^[2][3][4][5] The chemical reaction these enzymes catalyze is generally represented with the following equation:

NADH + H⁺ + acceptor ⇌ NAD⁺ + reduced acceptor

NADH dehydrogenase
Identifiers
EC no.	7.1.1.2
CAS no.	9079-67-8
Alt. names	cytochrome c reductase, type 1 dehydrogenase, beta-NADH dehydrogenase dinucleotide, diaphorase, dihydrocodehydrogenase I dehydrogenase, dihydronicotinamide adenine dinucleotide dehydrogenase, diphosphopyridine diaphorase, DPNH diaphorase, NADH diaphorase, NADH hydrogenase, NADH oxidoreductase, NADH-menadione oxidoreductase, reduced diphosphopyridine nucleotide diaphorase[1]
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

NADH dehydrogenase is a flavoprotein that contains iron-sulfur centers.

NADH dehydrogenase is used in the electron transport chain for generation of ATP.

The EC term NADH dehydrogenase (quinone) (EC 1.6.5.11) is defined for NADH dehydrogenases that use a quinone (excluding ubiquinone) as the acceptor. The EC term NADH dehydrogenase (ubiquinone) (EC 7.1.1.2) is defined for those with ubiquinone as the acceptor.