NAN-190

NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT_1A receptor antagonist, but a subsequent discovery showed that it also potently blocks the α₂-adrenergic receptor.^[1] The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin receptor antagonist.^[1]

NAN-190

Identifiers
IUPAC name 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine
CAS Number	102392-05-2 Y 115388-32-4 (hydrobromide)
PubChem CID	4431
IUPHAR/BPS	73
ChemSpider	4278 N
UNII	LQE19CTV54
ChEMBL	ChEMBL8618 N
CompTox Dashboard (EPA)	DTXSID3043813
Chemical and physical data
Formula	C23H27N3O3
Molar mass	393.487 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1c2ccccc2C(=O)N1CCCCN4CCN(CC4)c3ccccc3OC
InChI InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3 N Key:SJDOMIRMMUGQQK-UHFFFAOYSA-N N
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