Sialidase-4

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.^[5]

NEU4
Identifiers
Aliases	NEU4, neuraminidase 4
External IDs	OMIM: 608527; MGI: 2661364; HomoloGene: 15433; GeneCards: NEU4; OMA:NEU4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,809,065 bp[1] End 241,817,413 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,948,173 bp[2] End 93,956,056 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver substantia nigra duodenum temporal lobe amygdala hippocampus proper hypothalamus putamen anterior cingulate cortex Top expressed in striatum of neuraxis primary visual cortex Cortex of frontal lobe hypothalamus superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex hippocampus proper olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity hydrolase activity, acting on glycosyl bonds protein binding exo-alpha-(2->3)-sialidase activity hydrolase activity exo-alpha-sialidase activity Cellular component organelle inner membrane membrane lysosomal lumen lysosome cytoplasm intracellular membrane-bounded organelle Biological process glycosphingolipid metabolic process lipid metabolism lipid catabolic process glycoprotein catabolic process oligosaccharide catabolic process metabolism ganglioside catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129807 241159 Ensembl ENSG00000204099 ENSG00000277926 ENSMUSG00000034000 UniProt Q8WWR8 Q8BZL1 RefSeq (mRNA) NM_080741 NM_001167599 NM_001167600 NM_001167601 NM_001167602 NM_173772 NM_001310769 RefSeq (protein) NP_001161071 NP_001161072 NP_001161073 NP_001161074 NP_542779 NP_001161071.1 NP_001161072.1 NP_001161073.1 NP_001161074.1 NP_001297698 NP_776133 Location (UCSC) Chr 2: 241.81 – 241.82 Mb Chr 1: 93.95 – 93.96 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[5]

Interactions

Sialidase-4 has been shown to interact with phospholipid scramblase 1.^[6]