Neurogenin-2

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.^[5]

NEUROG2
Identifiers
Aliases	NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624; MGI: 109619; HomoloGene: 7633; GeneCards: NEUROG2; OMA:NEUROG2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 112,513,516 bp[1] End 112,516,180 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G2 Start 127,426,784 bp[2] End 127,429,280 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone gonad right hemisphere of cerebellum putamen amygdala caudate nucleus hippocampus proper prefrontal cortex anterior cingulate cortex Top expressed in ventricular zone rhombic lip fossa urethra ganglion of neuraxis ganglionic eminence pretectal area neural crest condyle zona limitans intrathalamica More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding E-box binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development nervous system development regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity neuron differentiation cell differentiation transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63973 11924 Ensembl ENSG00000178403 ENSMUSG00000027967 UniProt Q9H2A3 P70447 RefSeq (mRNA) NM_024019 NM_009718 RefSeq (protein) NP_076924 NP_033848 Location (UCSC) Chr 4: 112.51 – 112.52 Mb Chr 3: 127.43 – 127.43 Mb PubMed search [3] [4]
Wikidata
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Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.^[6]

It has been found to reprogram astrocytes to glutamatergic neurons when expressed.^[7]