Ninein

Ninein is a protein that in humans is encoded by the NIN gene.^[5][6][7]

NIN
Identifiers
Aliases	NIN, SCKL7, ninein
External IDs	OMIM: 608684; MGI: 105108; HomoloGene: 40632; GeneCards: NIN; OMA:NIN - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 50,719,763 bp[1] End 50,831,162 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 70,058,209 bp[2] End 70,160,491 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cardiac muscle tissue of right atrium tendon of biceps brachii bone marrow cell blood sural nerve monocyte trabecular bone skin of hip internal globus pallidus Top expressed in secondary oocyte primary oocyte granulocyte zygote tail of embryo decidua gastrula olfactory epithelium morula morula More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding calcium ion binding GTP binding protein binding kinase binding Cellular component cytoplasm microtubule organizing center spindle pole nucleolus pericentriolar material microtubule cytoskeleton mitotic spindle pole microtubule minus-end centrosome ciliary transition fiber nucleus centriole mitotic spindle centriolar subdistal appendage plasma membrane axon dendrite axonal growth cone apical part of cell Biological process centrosome localization centrosome-templated microtubule nucleation microtubule anchoring at centrosome protein localization centriole-centriole cohesion corpus callosum morphogenesis corticospinal tract morphogenesis positive regulation of microtubule polymerization collateral sprouting positive regulation of axonogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51199 18080 Ensembl ENSG00000100503 ENSMUSG00000021068 UniProt Q8N4C6 Q61043 RefSeq (mRNA) NM_016350 NM_020921 NM_182944 NM_182945 NM_182946 NM_001081453 NM_001286079 NM_001286080 NM_008697 RefSeq (protein) NP_057434 NP_065972 NP_891989 NP_891991 NP_001074922 NP_001273008 NP_001273009 NP_032723 NP_001390761 Location (UCSC) Chr 14: 50.72 – 50.83 Mb Chr 12: 70.06 – 70.16 Mb PubMed search [3] [4]
Wikidata
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Function

Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.^[7]

This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells.^[7]