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NMNAT3
From Wikipedia, the free encyclopedia
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Nicotinamide mononucleotide adenylyltransferase 3 (NMNAT3) is an enzyme that in humans is encoded by the NMNAT3 gene.[1]
NMNAT3 is the third of three protein isoforms of nicotinamide-nucleotide adenylyltransferase (NMNAT) found in humans.[2] As with the other NMNATs, NMNAT3 is an enzyme that catalyzes nicotinamide adenine dinucleotide (NAD) synthesis.[2] NMNAT3 levels are highest in liver, heart, skeletal muscle, and erythrocytes.[2]
NMNAT3 is localized in mitochondria or cytoplasm, depending upon the cell type.[3][4][5] Knockdown of NMNAT3 gene expression in cell culture strongly reduces mitochondrial function.[4] NMNAT3 is essential for maintaining NAD in red blood cells.[4]
The catechin epigallocatechin gallate found in tea can activate NMNAT3 by more than 40%.[5]
As of 2024, mutations in the NMNAT3 gene have not been associated with any known human disease,[2] but NMNAT3 deficiency causes hemolytic anemia in mice.[6]
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