NPS-2143

NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone.^[1] Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.^[2][3][4]

NPS-2143

Identifiers
IUPAC name 2-chloro-6-[(2R)-3-([1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino)-2-hydroxypropoxy]benzonitrile
CAS Number	284035-33-2 Y hydrochloride: 324523-20-8 Y
PubChem CID	6918446
IUPHAR/BPS	716
ChemSpider	5293643
UNII	Z25PJ77W7V hydrochloride: U48SZ6EBB3 Y
CompTox Dashboard (EPA)	DTXSID10426075
Chemical and physical data
Formula	C24H25ClN2O2
Molar mass	408.93 g·mol−1
3D model (JSmol)	Interactive image
SMILES N#Cc2c(Cl)cccc2OCC(O)CNC(C)(C)Cc3ccc1ccccc1c3
InChI InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1 Key:PZUJQWHTIRWCID-HXUWFJFHSA-N

See also

• Cinacalcet