Neuropeptide Y receptor Y1

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[5][6]

NPY1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F1U, 2IIL
Identifiers
Aliases	NPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDs	OMIM: 162641; MGI: 104963; HomoloGene: 700; GeneCards: NPY1R; OMA:NPY1R - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.2 Start 163,323,962 bp[1] End 163,344,832 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.1|8 33.15 cM Start 67,149,844 bp[2] End 67,159,444 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen popliteal artery tibial arteries right adrenal cortex left adrenal cortex Descending thoracic aorta adipose tissue germinal epithelium superficial temporal artery subcutaneous adipose tissue Top expressed in ascending aorta aortic valve dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex trigeminal ganglion muscle of thigh hippocampus proper posterior horn of spinal cord spinal ganglia More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity protein binding peptide YY receptor activity pancreatic polypeptide receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway locomotory behavior regulation of multicellular organism growth G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger outflow tract morphogenesis blood circulation regulation of blood pressure feeding behavior glucose metabolic process sensory perception of pain neuropeptide signaling pathway signal transduction chemical synaptic transmission G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4886 18166 Ensembl ENSG00000164128 ENSMUSG00000036437 UniProt P25929 Q04573 RefSeq (mRNA) NM_000909 NM_010934 NM_001358955 RefSeq (protein) NP_000900 NP_035064 NP_001345884 Location (UCSC) Chr 4: 163.32 – 163.34 Mb Chr 8: 67.15 – 67.16 Mb PubMed search [3] [4]
Wikidata
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Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

Available Structures

• 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)^[7]
• 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)^[7]

See also

• Neuropeptide Y receptor