Neuropeptide Y receptor Y2

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.^[5][6]

NPY2R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IK3
Identifiers
Aliases	NPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDs	OMIM: 162642; MGI: 108418; HomoloGene: 701; GeneCards: NPY2R; OMA:NPY2R - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 155,208,636 bp[1] End 155,217,078 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 E3|3 36.49 cM Start 82,445,690 bp[2] End 82,455,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle optic nerve pancreatic ductal cell lactiferous duct prefrontal cortex Hypothalamus tibialis anterior muscle nucleus accumbens right coronary artery Brodmann area 9 Top expressed in median eminence lumbar spinal ganglion arcuate nucleus dentate gyrus of hippocampal formation granule cell hippocampus proper anterior amygdaloid area subiculum CA3 field globus pallidus area postrema More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity calcium channel regulator activity signal transducer activity protein binding peptide YY receptor activity signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure non-motile cilium cilium Biological process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway regulation of sensory perception of pain locomotory behavior positive regulation of cytosolic calcium ion concentration positive regulation of peptide secretion outflow tract morphogenesis cardiac left ventricle morphogenesis negative regulation of nervous system process negative regulation of synaptic transmission behavioral fear response negative regulation of excitatory postsynaptic potential secretion positive regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of dopamine secretion negative regulation of secretion feeding behavior negative regulation of feeding behavior nitric oxide mediated signal transduction neuropeptide signaling pathway positive regulation of smooth muscle contraction negative regulation of synaptic transmission, glutamatergic signal transduction positive regulation of cell-substrate adhesion ageing chemical synaptic transmission G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4887 18167 Ensembl ENSG00000185149 ENSMUSG00000028004 UniProt P49146 P97295 RefSeq (mRNA) NM_000910 NM_001370180 NM_001375470 NM_001205099 NM_008731 RefSeq (protein) NP_000901 NP_001357109 NP_001362399 NP_001192028 NP_032757 Location (UCSC) Chr 4: 155.21 – 155.22 Mb Chr 3: 82.45 – 82.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• Peptide YY
• Peptide YY 3-36 fragment^[7]

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor