Neuropeptide Y receptor Y5

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.^[5][6][7]

NPY5R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HE6
Identifiers
Aliases	NPY5R, NPY5-R, NPYR5, NPYY5-R, Neuropeptide Y receptor Y5
External IDs	OMIM: 602001; MGI: 108082; HomoloGene: 21241; GeneCards: NPY5R; OMA:NPY5R - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.2 Start 163,343,892 bp[1] End 163,351,934 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.1|8 33.15 cM Start 67,132,617 bp[2] End 67,140,780 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle adipose tissue tibial arteries spleen subcutaneous adipose tissue Descending thoracic aorta prefrontal cortex right adrenal cortex left adrenal cortex abdominal fat Top expressed in lumbar subsegment of spinal cord suprachiasmatic nucleus substantia nigra embryo Region I of hippocampus proper neuron dentate gyrus of hippocampal formation granule cell facial motor nucleus nucleus accumbens arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity peptide YY receptor activity pancreatic polypeptide receptor activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane neuron projection Biological process G protein-coupled receptor signaling pathway negative regulation of glutamate secretion eating behavior outflow tract morphogenesis negative regulation of apoptotic process cardiac left ventricle morphogenesis negative regulation of synaptic transmission, GABAergic feeding behavior positive regulation of acute inflammatory response generation of ovulation cycle rhythm neuropeptide signaling pathway signal transduction positive regulation of smooth muscle cell proliferation positive regulation of cell population proliferation ageing chemical synaptic transmission negative regulation of acute inflammatory response to antigenic stimulus positive regulation of ERK1 and ERK2 cascade blood circulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4889 18168 Ensembl ENSG00000164129 ENSMUSG00000044014 UniProt Q15761 O70342 RefSeq (mRNA) NM_006174 NM_001317091 NM_001317092 NM_016708 NM_001358957 NM_001358958 RefSeq (protein) NP_001304020 NP_001304021 NP_006165 NP_057917 NP_001345886 NP_001345887 Location (UCSC) Chr 4: 163.34 – 163.35 Mb Chr 8: 67.13 – 67.14 Mb PubMed search [3] [4]
Wikidata
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Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• BWX-46 (selective NPY₅ agonist, CAS# 172997-92-1)
• Peptide YY

Antagonists

• CGP-71683 (CAS# 192322-50-2)
• FMS-586^[8]
• L-152,804 (CAS# 6508-43-6)
• Lu AA-33810^[9]
• MK-0557^[10]
• NTNCB (CAS# 486453-65-0)^[11]
• Velneperit (S-2367)

See also

• Neuropeptide Y receptor