Neuregulin 4

"NRG4" redirects here. For the cannabinoid drug, see RCS-4.

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.^[5][6][7]

NRG4
Identifiers
Aliases	NRG4, HRG4, neuregulin 4
External IDs	OMIM: 610894; MGI: 1933833; HomoloGene: 12921; GeneCards: NRG4; OMA:NRG4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.2 Start 75,935,969 bp[1] End 76,059,795 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 55,127,506 bp[2] End 55,234,128 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum secondary oocyte left testis olfactory zone of nasal mucosa right testis testicle muscle of thigh Top expressed in zygote brown adipose tissue secondary oocyte Glandular part of endometrium white adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle mammary gland primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding growth factor activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity signaling receptor binding Cellular component integral component of membrane membrane plasma membrane extracellular region intracellular anatomical structure extracellular space Biological process MAPK cascade ERBB2 signaling pathway phosphatidylinositol phosphate biosynthetic process peptidyl-tyrosine phosphorylation regulation of cell motility intracellular signal transduction animal organ development regulation of signaling receptor activity positive regulation of protein kinase B signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 145957 83961 Ensembl ENSG00000169752 ENSMUSG00000032311 UniProt Q8WWG1 Q9WTX4 RefSeq (mRNA) NM_138573 NM_032002 RefSeq (protein) NP_612640 NP_114391 Location (UCSC) Chr 15: 75.94 – 76.06 Mb Chr 9: 55.13 – 55.23 Mb PubMed search [3] [4]
Wikidata
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Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.^[7]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.^[8]