Neuropilin 2

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.^[5][6]

NRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Identifiers
Aliases	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
External IDs	OMIM: 602070; MGI: 1100492; HomoloGene: 2875; GeneCards: NRP2; OMA:NRP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 205,681,990 bp[1] End 205,798,133 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 62,742,444 bp[2] End 62,857,854 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa epithelium of colon muscle layer of sigmoid colon cartilage tissue body of uterus Achilles tendon smooth muscle tissue gallbladder left ovary Top expressed in calvaria body of femur habenula epithelium of bronchiole stroma of bone marrow dermis genital tubercle olfactory tubercle hair follicle tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor-activated receptor activity heparin binding semaphorin receptor activity growth factor binding metal ion binding cytokine binding protein binding identical protein binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane semaphorin receptor complex extracellular region axon glutamatergic synapse integral component of postsynaptic membrane Biological process sympathetic ganglion development cell differentiation semaphorin-plexin signaling pathway involved in neuron projection guidance positive regulation of endothelial cell proliferation vascular endothelial growth factor signaling pathway nervous system development axon guidance positive regulation of endothelial cell migration multicellular organism development sympathetic neuron projection guidance vascular endothelial growth factor receptor signaling pathway cell adhesion angiogenesis nerve development sympathetic neuron projection extension axon extension involved in axon guidance outflow tract septum morphogenesis neural crest cell migration neuron migration heart development facial nerve structural organization vestibulocochlear nerve structural organization gonadotrophin-releasing hormone neuronal migration to the hypothalamus ventral trunk neural crest cell migration negative chemotaxis trigeminal ganglion development sensory neuron axon guidance neural crest cell migration involved in autonomic nervous system development facioacoustic ganglion development dorsal root ganglion morphogenesis cellular response to leukemia inhibitory factor regulation of postsynapse organization viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8828 18187 Ensembl ENSG00000118257 ENSMUSG00000025969 UniProt O60462 O35375 RefSeq (mRNA) NM_003872 NM_018534 NM_201264 NM_201266 NM_201267 NM_201279 NM_001077403 NM_001077404 NM_001077405 NM_001077406 NM_001077407 NM_010939 RefSeq (protein) NP_003863 NP_061004 NP_957716 NP_957718 NP_957719 NP_958436 NP_001070871 NP_001070872 NP_001070873 NP_001070874 NP_001070875 NP_035069 Location (UCSC) Chr 2: 205.68 – 205.8 Mb Chr 1: 62.74 – 62.86 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is expressed by a wide variety of cell types. The transmembrane protein has been reported to bind to SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrins and ANGPTL4 to promote downstream signaling pathways. Consequently, NRP2 is known to play a role in cardiovascular development, axon guidance, tumorigenesis, inflammation and cardiovascular disease.^{[7][8][9][10]} Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[11]