Neurotrophin-4

Neurotrophin-4 (NT-4),^[5] also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[6] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.^[7][8] NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al^[9]

NTF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662; MGI: 97381; HomoloGene: 4503; GeneCards: NTF4; OMA:NTF4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,061,066 bp[1] End 49,065,076 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.3 cM Start 45,063,119 bp[2] End 45,066,603 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skeletal muscle tissue skin of abdomen muscle of thigh skin of leg gonad prostate mucosa of esophagus gastrocnemius muscle minor salivary glands Top expressed in hand Gonadal ridge molar sternocleidomastoid muscle tibialis anterior muscle upper arm knee joint triceps brachii muscle urothelium vas deferens More reference expression data BioGPS n/a
Gene ontology Molecular function neurotrophin p75 receptor binding signaling receptor binding protein binding growth factor activity Cellular component cytoplasmic vesicle extracellular region extracellular space synaptic vesicle axon dendrite Biological process negative regulation of neuron apoptotic process regulation of neuron differentiation adult locomotory behavior sensory organ boundary specification cell-cell signaling neuron projection morphogenesis innervation negative regulation of cell death long-term memory taste bud development mechanoreceptor differentiation transmembrane receptor protein tyrosine kinase signaling pathway ganglion mother cell fate determination epidermis development regulation of signaling receptor activity activation of phospholipase C activity neurotrophin TRK receptor signaling pathway peripheral nervous system development memory nerve development nerve growth factor signaling pathway modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4909 78405 Ensembl ENSG00000225950 ENSMUSG00000074121 UniProt P34130 Q80VU4 RefSeq (mRNA) NM_006179 NM_001395489 NM_198190 RefSeq (protein) NP_006170 NP_937833 Location (UCSC) Chr 19: 49.06 – 49.07 Mb Chr 7: 45.06 – 45.07 Mb PubMed search [3] [4]
Wikidata
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See also

• Tropomyosin receptor kinase B § Agonists