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Neurotensin receptor 2
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[5][6][7]
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Function
The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.[7] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.[8] NTS2 is found mostly in the brain through Northern-blot analysis.[8]Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.[8]
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