M7GpppN-mRNA hydrolase

M7GpppN-mRNA hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase.^{[1][2][3][4][5][6][7]} This enzyme catalyses the following chemical reaction

m7G5'ppp5'-mRNA + H₂O ${\displaystyle \rightleftharpoons }$ m7GDP + 5'-phospho-mRNA

M7GpppN-mRNA hydrolase
Identifiers
EC no.	3.6.1.62
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Decapping of mRNA is essential in eukaryotic mRNA turnover.