DCP2

This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[5][6][7]

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844; MGI: 1917890; HomoloGene: 13968; GeneCards: DCP2; OMA:DCP2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.2 Start 112,976,702 bp[1] End 113,022,195 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 44,513,569 bp[2] End 44,558,036 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte trabecular bone sperm parietal pleura placenta monocyte bone marrow visceral pleura epithelium of nasopharynx Top expressed in hand otolith organ utricle primitive streak superior cervical ganglion vas deferens condyle vestibular membrane of cochlear duct abdominal wall trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function m7G(5')pppN diphosphatase activity manganese ion binding metal ion binding protein binding exoribonuclease activity, producing 5'-phosphomonoesters RNA binding hydrolase activity 5'-3' exoribonuclease activity telomerase RNA binding Cellular component cytoplasm RISC complex cytosol P-body nucleoplasm cell junction nucleus cytoplasmic ribonucleoprotein granule Biological process mRNA catabolic process regulation of mRNA stability deadenylation-dependent decapping of nuclear-transcribed mRNA exonucleolytic catabolism of deadenylated mRNA histone mRNA catabolic process RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of telomere maintenance via telomerase regulation of telomerase RNA localization to Cajal body Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 167227 70640 Ensembl ENSG00000172795 ENSMUSG00000024472 UniProt Q8IU60 Q9CYC6 RefSeq (mRNA) NM_001242377 NM_152624 NM_027490 RefSeq (protein) NP_001229306 NP_689837 NP_081766 Location (UCSC) Chr 5: 112.98 – 113.02 Mb Chr 18: 44.51 – 44.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]

Interactions

DCP2 has been shown to interact with DCP1A^[8] and UPF1.^[6][9]