Nucleoporin 107

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.^[5][6][7]

NUP107
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CQC, 3CQG, 3I4R, 5A9Q
Identifiers
Aliases	NUP107, NUP84, NPHS11, nucleoporin 107kDa, nucleoporin 107, ODG6, ODG6; GAMOS7
External IDs	OMIM: 607617; MGI: 2143854; HomoloGene: 5555; GeneCards: NUP107; OMA:NUP107 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 68,686,951 bp[1] End 68,745,809 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 117,586,526 bp[2] End 117,628,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone Achilles tendon embryo ganglionic eminence rectum parietal pleura germinal epithelium gastric mucosa visceral pleura Top expressed in primitive streak tail of embryo oocyte primary oocyte secondary oocyte zygote yolk sac genital tubercle epiblast abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component cytosol centrosome nuclear membrane nuclear periphery membrane nuclear envelope nuclear pore nucleoplasm chromosome nuclear pore outer ring chromosome, centromeric region nucleus kinetochore host cell Biological process mRNA transport nuclear pore complex assembly regulation of transcription, DNA-templated protein import into nucleus viral transcription protein sumoylation mitotic nuclear membrane disassembly regulation of cellular response to heat protein transport posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery viral process tRNA export from nucleus sister chromatid cohesion intracellular transport of virus mRNA export from nucleus female gonad development regulation of gene silencing by miRNA regulation of glycolytic process transport nephron development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57122 103468 Ensembl ENSG00000111581 ENSMUSG00000052798 UniProt P57740 Q8BH74 RefSeq (mRNA) NM_020401 NM_001330192 NM_134010 RefSeq (protein) NP_001317121 NP_065134 NP_598771 Location (UCSC) Chr 12: 68.69 – 68.75 Mb Chr 10: 117.59 – 117.63 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[7]

Interactions

NUP107 has been shown to interact with NUP133.^[8][9]