Nucleoporin 85

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.^[5][6]

NUP85
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A9Q
Identifiers
Aliases	NUP85, Nup75, FROUNT, nucleoporin 85, NPHS17
External IDs	OMIM: 170285; MGI: 3046173; HomoloGene: 11755; GeneCards: NUP85; OMA:NUP85 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,205,659 bp[1] End 75,235,758 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,455,260 bp[2] End 115,474,811 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right testis gonad tibial nerve left testis mucosa of transverse colon right ovary right uterine tube oocyte Top expressed in fossa condyle primitive streak zygote primary oocyte ventricular zone epiblast Paneth cell secondary oocyte Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component cytoplasm nuclear membrane membrane nuclear envelope spindle nuclear pore chromosome nuclear pore outer ring chromosome, centromeric region cytoskeleton kinetochore nucleus cytosol host cell Biological process mRNA transport protein import into nucleus viral transcription protein sumoylation positive regulation of transcription, DNA-templated chemotaxis mitotic nuclear membrane disassembly macrophage chemotaxis regulation of cellular response to heat protein transport viral process lamellipodium assembly intracellular transport of virus mRNA export from nucleus tRNA export from nucleus sister chromatid cohesion regulation of gene silencing by miRNA regulation of glycolytic process transport nephron development nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79902 445007 Ensembl ENSG00000125450 ENSMUSG00000020739 UniProt Q9BW27 Q8R480 RefSeq (mRNA) NM_001303276 NM_024844 NM_001330472 NM_001002929 RefSeq (protein) NP_001290205 NP_001317401 NP_079120 NP_001002929 Location (UCSC) Chr 17: 75.21 – 75.24 Mb Chr 11: 115.46 – 115.47 Mb PubMed search [3] [4]
Wikidata
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Function

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.^[6]