Nucleoporin 88

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.^[5][6]

NUP88
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 7R5J, 7R5K, 7TDZ, 7VOP
Identifiers
Aliases	NUP88, nucleoporin 88, FADS4
External IDs	OMIM: 602552; MGI: 104900; HomoloGene: 1901; GeneCards: NUP88; OMA:NUP88 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 5,360,963 bp[1] End 5,419,676 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B4|11 43.21 cM Start 70,833,884 bp[2] End 70,860,799 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis oocyte gonad right lobe of liver secondary oocyte sperm mucosa of transverse colon left lobe of thyroid gland ventricular zone Top expressed in tail of embryo zygote genital tubercle secondary oocyte medial ganglionic eminence spermatocyte primary oocyte abdominal wall ventricular zone epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity structural constituent of nuclear pore Cellular component cytosol nuclear pore nucleoplasm nucleus host cell Biological process mRNA transport protein import into nucleus protein transport viral process mRNA export from nucleus mitotic cell cycle ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus nucleocytoplasmic transport protein export from nucleus regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4927 19069 Ensembl ENSG00000108559 ENSMUSG00000040667 UniProt Q99567 Q8CEC0 RefSeq (mRNA) NM_002532 NM_001320653 NM_001083331 NM_001276406 NM_172394 RefSeq (protein) NP_001307582 NP_002523 NP_001076800 NP_001263335 NP_765982 Location (UCSC) Chr 17: 5.36 – 5.42 Mb Chr 11: 70.83 – 70.86 Mb PubMed search [3] [4]
Wikidata
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Function

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias.^[6]

Interactions

NUP88 has been shown to interact with NUP98.^[7]