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Naphthylmorpholine

Pharmaceutical compound From Wikipedia, the free encyclopedia

Naphthylmorpholine
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Naphthylmorpholine (code name PAL-678), also known as 2-(2′-naphthyl)morpholine, is a monoamine releasing agent of the arylmorpholine and naphthylethylamine families.[1][2] It is the derivative of 2-phenylmorpholine with a 2-naphthalene ring instead of a phenyl ring.[1][2] Naphthylmorpholine is a close analogue of naphthylmetrazine (PAL-704; a naphthalene analogue of phenmetrazine), but lacks naphthylmetrazine's methyl group at the 3 position of the morpholine ring.[1][2]

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The drug is a potent monoamine releasing agent.[1] Its EC50Tooltip half-maximal effective concentration values for induction of monoamine release have not been reported, but it released 92% of serotonin, 88% of norepinephrine, and 79% of dopamine at a concentration of 10,000 nM in rat brain synaptosomes.[1] Hence, it appears to act preferentially as a releaser of serotonin and norepinephrine and to a lesser extent of dopamine.[1]

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