Poliovirus receptor-related 2

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Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.^[5]

NECTIN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	OMIM: 600798; MGI: 97822; HomoloGene: 86092; GeneCards: NECTIN2; OMA:NECTIN2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,846,175 bp[1] End 44,889,223 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.94 cM Start 19,450,569 bp[2] End 19,484,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium olfactory zone of nasal mucosa apex of heart right lobe of liver gallbladder right testis left adrenal cortex body of stomach mucosa of transverse colon upper lobe of left lung Top expressed in yolk sac transitional epithelium of urinary bladder Ileal epithelium decidua gastrula lumbar spinal ganglion endothelial cell of lymphatic vessel duodenum epiblast crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function coreceptor activity virus receptor activity protein binding identical protein binding signaling receptor binding cell adhesion molecule binding protein heterodimerization activity protein homodimerization activity Cellular component integral component of membrane membrane cell-cell junction focal adhesion plasma membrane integral component of plasma membrane cell surface zonula adherens extracellular exosome apical junction complex cell-cell contact zone Biological process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules sperm mitochondrion organization cell recognition positive regulation of immunoglobulin mediated immune response regulation of viral entry into host cell susceptibility to natural killer cell mediated cytotoxicity positive regulation of mast cell activation cell adhesion acrosome assembly cytoskeleton organization positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cilium organization establishment of mitochondrion localization spermatid development regulation of immune response fertilization spermatid nucleus differentiation susceptibility to T cell mediated cytotoxicity viral process cell part morphogenesis adherens junction organization positive regulation of natural killer cell mediated cytotoxicity homophilic cell adhesion via plasma membrane adhesion molecules viral entry into host cell signal transduction positive regulation of T cell receptor signaling pathway virion attachment to host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5819 19294 Ensembl ENSG00000130202 ENSMUSG00000062300 UniProt Q92692 P32507 RefSeq (mRNA) NM_001042724 NM_002856 NM_001159724 NM_008990 RefSeq (protein) NP_001036189 NP_002847 NP_001153196 NP_033016 Location (UCSC) Chr 19: 44.85 – 44.89 Mb Chr 7: 19.45 – 19.48 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]

See also

• Cluster of differentiation