NeuroD

NeuroD, also called Beta2, is a basic helix-loop-helix transcription factor expressed in certain parts of brain, beta pancreatic cells and enteroendocrine cells. It is involved in the differentiation of nervous system and development of pancreas.^[1] It heterodimerizes with the products of E2A gene and controls the transcription of a variety of genes by identifying and binding E boxes in their promoter region. In rodents NeuroD is involved in the development of the retina.^[2]

In mammals there are two types of this factor:

• NeuroD1
• NeuroD2
• NeuroD4
• NeuroD6