Neuromedin U receptor

The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S.^[1] There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (NMUR1, NMUR2).

neuromedin U receptor 1
Identifiers
Symbol	NMUR1
Alt. symbols	GPR66
NCBI gene	10316
HGNC	4518
OMIM	604153
RefSeq	NM_006056
UniProt	Q9HB89
Other data
Locus	Chr. 2 q37.1
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neuromedin U receptor 2
Identifiers
Symbol	NMUR2
Alt. symbols	NMU2R
NCBI gene	56923
HGNC	16454
OMIM	605108
RefSeq	NM_020167
UniProt	Q9GZQ4
Other data
Locus	Chr. 5 q33.1
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Selective Ligands

Neuromedin U is an agonist at both the NMU₁ and NMU₂ subtypes, while neuromedin S is selective for NMU₂, and is a more potent agonist at this subtype than neuromedin U.^[2][3] Several other peptide and non-peptide ligands are also available for the NMU receptors.

Agonists

Non-selective

• Neuromedin U
• non-peptide NMU modulators ^[4][5]

NMU₂ selective

• Neuromedin S

Antagonists

NMU₂ selective

• R-PSOP ^[6]