Nuclear receptor 4A3

The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene.^[5] NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.

NR4A3
Identifiers
Aliases	NR4A3, CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3
External IDs	OMIM: 600542; MGI: 1352457; HomoloGene: 5074; GeneCards: NR4A3; OMA:NR4A3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 99,821,855 bp[1] End 99,866,891 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 48,045,153 bp[2] End 48,086,447 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus mucosa of urinary bladder tail of epididymis gastric mucosa vena cava muscle of thigh gallbladder right ventricle popliteal artery tibial arteries Top expressed in Region I of hippocampus proper seminal vesicula medulla of thymus hippocampus proper adrenal gland dentate gyrus dentate gyrus of hippocampal formation granule cell Amygdala subiculum extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding protein homodimerization activity DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding steroid hormone receptor activity nuclear receptor activity core promoter sequence-specific DNA binding protein binding histone acetyltransferase binding glucocorticoid receptor binding transcription coactivator binding protein kinase binding DNA-binding transcription factor activity, RNA polymerase II-specific cAMP response element binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component transcription regulator complex mast cell granule nucleoplasm nucleus Biological process negative regulation of neuron apoptotic process cellular response to catecholamine stimulus semicircular canal morphogenesis regulation of transcription, DNA-templated neuromuscular process controlling balance positive regulation of epithelial cell proliferation common myeloid progenitor cell proliferation pyruvate oxidation negative regulation of oxidative stress-induced neuron death mesoderm formation response to peptide hormone negative regulation of apoptotic process positive regulation of leukocyte apoptotic process negative regulation of transcription by RNA polymerase II regulation of smooth muscle cell proliferation cellular response to leptin stimulus transcription, DNA-templated positive regulation of cardiac muscle hypertrophy axon guidance positive regulation of transcription, DNA-templated adult behavior positive regulation of cell cycle negative regulation of hydrogen peroxide-induced neuron death gastrulation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway animal organ regeneration inner ear morphogenesis positive regulation of mast cell cytokine production cellular respiration vestibular reflex energy homeostasis cellular response to corticotropin-releasing hormone stimulus mast cell degranulation transcription initiation from RNA polymerase II promoter positive regulation of feeding behavior positive regulation of glucose transmembrane transport hippocampus development positive regulation of monocyte aggregation fat cell differentiation response to hydrogen peroxide regulation of type B pancreatic cell proliferation positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway positive regulation of smooth muscle cell proliferation positive regulation of fatty acid oxidation intracellular receptor signaling pathway regulation of megakaryocyte differentiation platelet-derived growth factor receptor signaling pathway positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8013 18124 Ensembl ENSG00000119508 ENSMUSG00000028341 UniProt Q92570 Q9QZB6 RefSeq (mRNA) NM_006981 NM_173198 NM_173199 NM_173200 NM_015743 NM_001307989 RefSeq (protein) NP_008912 NP_775291 NP_775292 NP_001294918 NP_056558 Location (UCSC) Chr 9: 99.82 – 99.87 Mb Chr 4: 48.05 – 48.09 Mb PubMed search [3] [4]
Wikidata
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NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration,^[6] metabolism^[7][8] and apoptosis^[9]

Interactions

NR4A3 has been shown to interact with SIX3.^[10][11]

See also

• NUR nuclear receptor family