Enolase 2

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.^[5][6] Gamma-enolase is a phosphopyruvate hydratase.

ENO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TE6, 2AKM, 2AKZ, 3UCC, 3UCD, 3UJE, 3UJF, 3UJR, 3UJS, 4ZCW, 4ZA0
Identifiers
Aliases	ENO2, HEL-S-279, NSE, Enolase 2
External IDs	OMIM: 131360; MGI: 95394; HomoloGene: 74414; GeneCards: ENO2; OMA:ENO2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,913,745 bp[1] End 6,923,698 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,737,016 bp[2] End 124,746,636 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum paraflocculus of cerebellum cerebellar vermis Brodmann area 10 right frontal lobe frontal pole Brodmann area 9 postcentral gyrus cingulate gyrus Top expressed in motor neuron pontine nuclei cerebellar cortex subiculum superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell superior colliculus primary motor cortex lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding lyase activity magnesium ion binding phosphopyruvate hydratase activity Cellular component cytoplasm cytosol plasma membrane phosphopyruvate hydratase complex extracellular exosome extracellular space membrane photoreceptor inner segment soma perikaryon intracellular anatomical structure myelin sheath Biological process gluconeogenesis canonical glycolysis glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2026 13807 Ensembl ENSG00000111674 ENSMUSG00000004267 UniProt P09104 Q6FHV6 P17183 RefSeq (mRNA) NM_001975 NM_013509 NM_001302642 NM_001355220 RefSeq (protein) NP_001966 NP_001966.1 NP_001289571 NP_038537 NP_001342149 Location (UCSC) Chr 12: 6.91 – 6.92 Mb Chr 6: 124.74 – 124.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

Utility

Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.

Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.^[7]