Nexafed

Nexafed is a formulation of pseudoephedrine developed by Acura Pharmaceuticals used to deter the use of the pseudoephedrine contained in the product for illicit methamphetamine synthesis.^[1] Nexafed uses a polymer matrix that forms a thick gel when hydrated, preventing the extraction of pseudoephedrine.^[2] Nexafed is the only meth-resistant formulation of pseudoephedrine that shows therapeutic equivalence to Sudafed.^[3]

It is sold at various pharmacies in the US, including Fruth Pharmacy^[4][5] and Kroger, particularly in communities where illicit methamphetamine production is an issue.^{[citation needed]}