Nobiletin

Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.^[1]

Nobiletin

Names
IUPAC name 3′,4′,5,6,7,8-Hexamethoxyflavone
Systematic IUPAC name 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
Other names Hexamethoxyflavone
Identifiers
CAS Number	478-01-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:7602 N
ChemSpider	65283 N
KEGG	C10112 N
PubChem CID	72344
UNII	D65ILJ7WLY Y
CompTox Dashboard (EPA)	DTXSID30197275
InChI InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 N Key: MRIAQLRQZPPODS-UHFFFAOYSA-N N InChI=1/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3 Key: MRIAQLRQZPPODS-UHFFFAOYAI
SMILES c1c(OC)c(OC)ccc1C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
Properties
Chemical formula	C21H22O8
Molar mass	402.399 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Potential pharmacology

Nobiletin was found to potentially inhibit cartilage degradation.^[2]

Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture.^[3] Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.^[4] Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer[5].