Technetium (99mTc) nofetumomab merpentan

Technetium (^99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,^[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.^[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (^99mTc).^[3]

Technetium (^99mTc) nofetumomab merpentan

Monoclonal antibody
Type	Fab fragment
Source	Mouse
Clinical data
Trade names	Verluma
ATC code	none
Pharmacokinetic data
Elimination half-life	10.5 hours
Excretion	renal (64%)
Identifiers
CAS Number	165942-79-0 N
ChemSpider	none
UNII	9UFH75HT7S
NY (what is this?)  (verify)

Nofetumomab

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.^[4] and/or CD20/MS4A1^[5]

It is the Fab part of murine MAb NR-LU-10.^[6]

Merpentan

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.^[6]

Phenthioate

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate^[7]