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Noroxycodone
Chemical compound From Wikipedia, the free encyclopedia
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Noroxycodone is the major metabolite of the opioid analgesic oxycodone.[1][2][3] It is formed from oxycodone in the liver via N-demethylation predominantly by CYP3A4.[1][2][3] Noroxycodone binds to and activates the μ-opioid receptor (MOR) similarly to oxycodone, although with one-third of the affinity of oxycodone and 5- to 10-fold lower activational potency.[1][4][5] However, although a potent MOR agonist, noroxycodone poorly crosses the blood-brain-barrier into the central nervous system, and for this reason, is only minimally analgesic in comparison.[6][5][4][7]
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