Norsalsolinol

Norsalsolinol is a tetrahydroisoquinoline that is produced naturally in the body through the metabolism of dopamine.^[1] It has been shown to be a selective dopaminergic neurotoxin,^[2][3][4] and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease and the brain damage associated with alcoholism,^[5][6] although evidence for a causal relationship is unclear.^[7][8][9]

Norsalsolinol

Names
Preferred IUPAC name 1,2,3,4-Tetrahydroisoquinoline-6,7-diol
Other names 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
Identifiers
CAS Number	34827-33-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:173739
ChemSpider	33891 N
PubChem CID	36937
UNII	9SPO03ZH41 Y
CompTox Dashboard (EPA)	DTXSID90188366
InChI InChI=1S/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2 N Key: MBFUSGLXKQWVDW-UHFFFAOYSA-N N InChI=1/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2 Key: MBFUSGLXKQWVDW-UHFFFAOYAF
SMILES C1CNCC2=CC(=C(C=C21)O)O
Properties
Chemical formula	C9H11NO2
Molar mass	165.189 g/mol
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Neurotoxin
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

The related compound (R)-salsolinol, which has been shown to be a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake in rats.^[10]

See also

• Substituted tetrahydroisoquinoline
• 6-Hydroxydopamine
• MPTP
• Rotenone