Phorbol-12-myristate-13-acetate-induced protein 1

"Noxa" redirects here. For the Indonesian grindcore band, see Noxa (band).

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.^[3][4][5]

PMAIP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3MQP
Identifiers
Aliases	PMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDs	OMIM: 604959; HomoloGene: 88883; GeneCards: PMAIP1; OMA:PMAIP1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.32 Start 59,899,948 bp[1] End 59,904,306 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cartilage tissue oral cavity gonad monocyte skin of thigh nipple human penis bone marrow palpebral conjunctiva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol mitochondrial outer membrane mitochondrion nucleus Biological process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors response to dsRNA cellular response to glucose starvation positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of glucose metabolic process reactive oxygen species metabolic process cellular response to DNA damage stimulus positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of mitochondrial membrane permeability defense response to virus positive regulation of protein oligomerization positive regulation of release of cytochrome c from mitochondria proteasomal protein catabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway cellular response to hypoxia release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway apoptotic process regulation of apoptotic process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway negative regulation of mitochondrial membrane potential T cell homeostasis positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5366 n/a Ensembl ENSG00000141682 n/a UniProt Q13794 n/a RefSeq (mRNA) NM_021127 n/a RefSeq (protein) NP_066950 NP_001369544 NP_001369545 NP_001369546 NP_001369547 NP_001369552 n/a Location (UCSC) Chr 18: 59.9 – 59.9 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.^[6] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

• BCL2-like 1,^[7][8]
• Bcl-2,^[7][8] and
• MCL1.^[7][9][10]

See also

• Apoptosis
• Apoptosome
• Bcl-2
• Bcl-2-associated X protein (BAX)
• BH3 interacting domain death agonist (BID)
• Caspases
• Cytochrome c
• Mitochondrion
• p53 upregulated modulator of apoptosis (PUMA)
• 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)